Osphena (ospemifene) is the only FDA-approved non-estrogen, oral pill for moderate to severe painful sex due to menopause.
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Vaginal tissue changes.
It's common.

As your estrogen levels naturally decline after menopause, the resulting changes in vaginal tissue can cause sex to be painful.

More about vaginal changes due to menopause

If you think you're experiencing moderate to severe painful sex due to menopause, take charge and do something about it.

Osphena® may be able to help with moderate to severe painful intercourse due to menopause, without the hormones.

  • An oral pill
  • NON-ESTROGEN
  • Rebuilds specific vaginal tissue

Osphena improves specific physical changes of the vagina (specific physical changes include superficial and parabasal cells, and pH of the vagina).

What is Osphena?
Osphena works at the cellular level -- or from the inside out.

Osphena is the only FDA-approved, non-estrogen, oral treatment for moderate to severe painful intercourse due to menopause. In 12 weeks, Osphena physically changes the vagina at the cellular level by rebuilding specific vaginal tissue, which can significantly relieve moderate to severe painful sex due to menopause. Lubricants can't do that.

Osphena improves specific physical changes of the vagina (specific physical changes include superficial and parabasal cells, and pH of the vagina).

Your Osphena® Savings Program 2 WAYS to SAVE* on Your Osphena Prescription

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*Some restrictions apply. The Osphena Savings Card is not available for Medicare Part D, Medicaid, or other federal or state insurance
program participants. See eligibility rules and full program terms and conditions, including maximum benefit, on the Savings Card.

Be proactive in talking with your doctor.

Sex after menopause shouldn’t have to hurt. Believe it or not, many healthcare providers rarely bring up painful intercourse in conversation with their patients. And many women experiencing moderate to severe painful sex due to menopause never initiate a conversation with their healthcare providers about it. Take action. Set up an appointment. Be ready to talk about it. Start the conversation with your doctor. Ask about Osphena.

Talk to your doctor
Have Questions? Call Us 1.855.OSPHENA. M-F 8 AM - 8 PM EST

Indication and Important Safety Information

Important Safety Information and Indication

What is Osphena® (ospemifene) tablets?

Osphena is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Important Safety Information for Osphena

Most Important Information you should know about Osphena®

Osphena works like estrogen in the lining of the uterus, but can work differently in other parts of the body. Taking estrogen alone or Osphena may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause; so tell them right away if this happens while you are using Osphena.

Osphena may increase your chance of getting strokes and blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena.

Call your healthcare provider right away if you get changes in vision or speech, sudden new severe headaches, and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue. Osphena should not be used if you have unusual vaginal bleeding; have or have had certain types of cancers (including cancer of the breast or uterus); have or had blood clots; had a stroke or heart attack; have severe liver problems; are allergic to Osphena or any of its ingredients; or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Possible side effects of Osphena

Serious but less common side effects can include stroke, blood clots, and cancer of the lining of the uterus.

Common side effects can include hot flashes, vaginal discharge, muscle spasms and increased sweating.

Tell your healthcare provider about all of the medicines and supplements you take as some medicines may affect how Osphena works. Osphena may also affect how other medicines work.

What is Osphena® (ospemifene) tablets?

Osphena is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Please read accompanying Patient Information for Osphena® (ospemifene) tablets, including Boxed WARNING in the U.S. Full Prescribing Information.