After menopause, estrogen levels decline, which causes the vagina to change — and sex can become painful.

But it's treatable.

Menopause causes vaginal changes.

Menopause — for women, it’s a fact of life. As we age, a decline in estrogen changes the vaginal tissues, which can lead to painful sex.

As your estrogen levels start to naturally decline with age, the vagina can become shorter and narrower. And your vaginal tissue thins, becoming quite painful.


The medical term for painful sex is dyspareunia (pronounced dis-puh-roo-nee-uh). Painful sex is one of the most bothersome symptoms of vulvar and vaginal atrophy (VVA).

Fact: It's very common.

Wondering if you are the only one experiencing painful sex after menopause? The answer is NO — not by a longshot. It's not just you — it’s very natural and normal. You are one of the millions of women experiencing it.

Here are the stats:

  • 32 million women will experience vaginal changes due to menopause.
  • Vulvar and vaginal atrophy happens to approximately 50% of all women after menopause.
  • It is estimated as many as 1 in 3 women diagnosed with vulvar and vaginal atrophy due to menopause experience painful sex.

We spend about one-third of our lives after menopause. Sure, we might be a bit older now, but that doesn’t mean we’re not having sex anymore. Sex is healthy. Unlike hot flashes, painful sex will not go away on its own. Left untreated, it can get worse. So, isn’t it time to speak up and talk to your healthcare provider about it?

Osphena® works at the cellular level.

Osphena is the only FDA-approved, non-estrogen, oral treatment for moderate to severe painful intercourse due to menopause. Osphena physically changes the vagina at the cellular level by helping repair and rebuild specific vaginal tissue, which can significantly relieve moderate to severe painful sex due to menopause. Lubricants can offer temporary relief of painful sex, but they can’t repair and rebuild the tissue.

  • Sex
  • after menopause
  • shouldn't have to hurt.
Osphena improves specific physical changes of the vagina (specific physical changes include superficial and parabasal cells, and pH of the vagina).

Osphena actually helps
rebuild the specific
vaginal tissue that
causes the pain.
Lubricants can't do that.

Osphena improves specific physical changes of the vagina (specific physical
changes include superficial and parabasal cells, and pH of the vagina).

Take charge and start the conversation with your doctor. Ask about Osphena®.

Sex after menopause is still important. If you’re living with painful sex in silence, stop the silence now. You deserve to be heard.

Not sure what to say? Download a doctor discussion guide to help you prepare for an effective talk with your doctor about treatment options.

Download My Guide

Click here to print US Full Prescribing Information

Have questions? Call us!

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  • M-F 8AM-8PM EST

Important Safety Information and Indication

Most Important Information You Should Know About Osphena®

Osphena® (ospemifene) works like estrogen in the lining of the uterus, but can work differently in other parts of the body.

Taking estrogen alone or Osphena® may increase your chance for getting cancer of the lining of the uterus, strokes, and blood clots. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause, so tell them right away if this happens while you are using Osphena®.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena®.

Call your healthcare provider right away if you get changes in vision or speech, sudden new severe headaches, and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue. Osphena® should not be used if you have unusual vaginal bleeding; have or have had certain types of cancers (including cancer of the breast or uterus); have or had blood clots; had a stroke or heart attack; have severe liver problems; or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Possible Side Effects

Serious but less common side effects can include stroke, blood clots, and cancer of the lining of the uterus.

Common side effects can include hot flashes, vaginal discharge, muscle spasms and increased sweating.

Tell your healthcare provider about all of the medicines you take as some medicines may affect how Osphena® works. Osphena® may also affect how other medicines work.

What is Osphena?

Osphena (ospemifene) is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Please read the Patient Information for Osphena® (ospemifene) tablets, including Boxed WARNING in the Full Prescribing Information.