Osphena® — the only FDA-approved, non-estrogen, oral pill for moderate to severe painful sex due to menopause.

Why can sex become painful after menopause?

What you're feeling is real. Your body goes through a lot of changes after menopause. The body ages — so does the vagina.

What happens to the vagina?
Vaginal changes are common and normal after menopause. The changes are because of declining estrogen levels. As we approach menopause, our hormone levels start to fluctuate. Once menopause occurs, our estrogen levels naturally decline, which causes our vaginal tissue to change. For some women, sex can become very painful.


It's a real medical condition many women don't realize is related to menopause. The medical term for painful intercourse due to menopause is dyspareunia (pronounced dis-puh-roo-nee-uh). Painful sex is one of the most bothersome symptoms of vulvar and vaginal atrophy (VVA).

More about vaginal changes due to menopause

Have you wondered:

Am I the only one experiencing this?

The answer is NO — not by a long shot.

Painful sex after menopause -- It's surprisingly common.

Osphena® may be able to help with moderate to severe painful intercourse due to menopause, without the hormones.

  • An oral pill
  • Improves specific vaginal tissue
What is Osphena?
Osphena improves specific vaginal tissue.

Osphena is the only FDA-approved, non-estrogen, oral treatment for moderate to severe dyspareunia due to menopause. Osphena works at the cellular level by improving specific vaginal tissue, which can significantly relieve moderate to severe painful sex due to menopause. Lubricants can't do that.

More About Osphena

Make an appointment.
Start the conversation
with your doctor.
Ask About Osphena®.

The first step for you? Take action. Set up an appointment. Be ready to talk about it. Don't be ashamed to talk about moderate to severe painful sex — if you don't, your doctor may not know there is an issue. They may figure, if you had symptoms, you would say something. So, speak up. Ask about Osphena. This will help start the conversation. Talk to your doctor, whether it's a gynecologist, primary care physician, or menopause specialist.

Not sure what to say? Download a doctor discussion guide to help you prepare for an effective talk with your doctor about treatment options.

Download my Guide

Click here to print US Full Prescribing Information

In a survey of postmenopausal women, results showed that


of healthcare providers don't
proactively ask about sexual health.

Source: Kingsberg SA, et al. Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (Real Women's Views of Treatment Options for Menopausal Vaginal Changes) survey. J Sex Med. 2013;10(7):1790-9.

Find a Certified Menopause Practitioner

Your Osphena® Savings Program 2 WAYS to SAVE* on Your Osphena Prescription

  • Ribbon
  • Savings Card
  • Ribbon


1. Click on the "Download Savings Card" link above and print your personalized savings card.

2. Activate your card by calling 1-877-208-2559.

3. Present this offer to your pharmacist along with a valid 30 or 90 day prescription for Osphena (ospemifene).

4. Each card provides savings for up to a 6 month supply.

*Some restrictions apply. The Osphena Savings Card is not available for Medicare Part D, Medicaid, or other federal or state insurance
program participants. See eligibility rules and full program terms and conditions, including maximum benefit, on the Savings Card.

Osphena at Home


Once you have your prescription for Osphena, there’s no need to run to the pharmacy.

Take a break from your errands, and get Osphena delivered to your door.

Home Delivery Frequently Asked Questions


Have Questions? Call Us 1.855.OSPHENA. M-F 8 AM - 8 PM EST

Indication and Important Safety Information

Important Safety Information and Indication

What is Osphena® (ospemifene) tablets?

Osphena is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Important Safety Information for Osphena

Most Important Information you should know about Osphena®

Osphena works like estrogen in the lining of the uterus, but can work differently in other parts of the body. Taking estrogen alone or Osphena may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause; so tell them right away if this happens while you are using Osphena.

Osphena may increase your chance of getting strokes and blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena.

Call your healthcare provider right away if you get changes in vision or speech, sudden new severe headaches, and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue. Osphena should not be used if you have unusual vaginal bleeding; have or have had certain types of cancers (including cancer of the breast or uterus); have or had blood clots; had a stroke or heart attack; have severe liver problems; are allergic to Osphena or any of its ingredients; or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Possible side effects of Osphena

Serious but less common side effects can include stroke, blood clots, and cancer of the lining of the uterus.

Common side effects can include hot flashes, vaginal discharge, muscle spasms and increased sweating.

Tell your healthcare provider about all of the medicines and supplements you take as some medicines may affect how Osphena works. Osphena may also affect how other medicines work.

What is Osphena® (ospemifene) tablets?

Osphena is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Please read accompanying Patient Information for Osphena® (ospemifene) tablets, including Boxed WARNING in the U.S. Full Prescribing Information.