Osphena^® FAQs Find answers here

Osphena^® is the first and only FDA-approved oral pill for the treatment of moderate to severe vaginal dryness and/or moderate to severe dyspareunia (painful sex), symptoms of vulvar and vaginal atrophy (VVA), due to menopause. Osphena^® helps improve specific vaginal tissue* to relieve moderate to severe vaginal dryness and moderate to severe painful sex due to menopause.

*Increases superficial cells, decreases parabasal cells (these are two types of vaginal cells) and reduces vaginal pH.

Before menopause, estrogen helps your body produce fluid that keeps the walls of your vagina lubricated. As estrogen levels fall during menopause, your body produces less of this lubricant, which can lead to vaginal dryness.

Before menopause, high levels of estrogen stimulate maturation of the vaginal lining to generate a thick layer of mature superficial cells. After menopause, a lack of estrogen leaves the vaginal lining much thinner, with very few or no superficial cells. In many women, this thinning is associated with vaginal dryness, irritation, itching and pain with intercourse, a condition referred to as vaginal atrophy or atrophic vaginitis.

In clinical studies, most women reported relief of moderate to severe vaginal dryness and/or moderate to severe painful sex due to menopause in as little as 12 weeks after beginning treatment with Osphena^®. You and your healthcare provider should talk regularly about whether or not you still need treatment with Osphena^®.

Many women with moderate to severe vaginal dryness use over-the-counter lubricants or moisturizers to provide relief from daily discomfort. Many also use over-the-counter lubricants to make sex less painful. However, lubricants only provide temporary relief and do nothing to treat the underlying causes of vaginal dryness or dyspareunia. It is important to know that if left untreated, both vaginal dryness and dyspareunia can get worse. That’s why, if you're experiencing moderate to severe vaginal dryness and/or dyspareunia due to menopause, you should talk to your healthcare provider about Osphena^®. With continued use, Osphena^® can improve specific vaginal tissue* and help relieve moderate to severe vaginal dryness and/or dyspareunia due to menopause.

*Increases superficial cells, decreases parabasal cells (two types of vaginal cells) and reduces vaginal pH.

Osphena^® is not for everyone. Do not take Osphena^® if you:

• Have unusual vaginal bleeding
• Have or have had certain types of cancers (including cancer of the breast or uterus)
• Have or have had blood clots
• Have had a stroke or heart attack
• Have severe liver problems
• Are allergic to Osphena^® or any of its ingredients
• Think you may be pregnant

Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Call 1-855-Osphena (1-855-677-4362), Monday to Friday, from 8:30 am to 4:30 pm EST.

Take Osphena^® exactly how your healthcare provider tells you to take it: once a day, by mouth, with food. Talk with your healthcare provider regularly about whether you should continue treatment with Osphena^®.

Tell your healthcare provider about any prescription and non-prescription medicines or supplements you take, as some medicines may affect how Osphena^® works. Osphena^® may also affect how other medicines work.

Yes. Take Osphena^® once a day, every day, with food, as directed by your doctor.

Take your next regularly scheduled pill. Do not take two pills in the same day.

Talk with your healthcare provider about whether you should continue treatment with Osphena^®.

Yes. However, in clinical studies, fewer women taking Osphena^® were using lubricant by week 12.

Osphena At Home^®, offered through PhilRx, provides discreet free home delivery, on-staff pharmacists to answer product questions, assistance with insurance benefit verification and monthly refill reminders.

Call (844) 716-HOME (4663) Monday to Friday, from 9am to 8pm EST or Sunday 9am to 1pm EST.

There are several ways to enroll:

• By telephone: Call (844) 716-HOME (4663) to speak to a PhilRx representative who will confirm your address and insurance information, explain the program and provide you with your insurance co-pay and delivery options
• At your healthcare provider’s office: During your office visit, ask your healthcare provider about the program so that he/she can fax your prescription or e-prescribe directly to us. Once the fax or e-prescription has been received, a Transition Pharmacy representative will contact you to confirm your address and insurance information and provide you with your co-pay amount and delivery options

Enrolling by telephone takes just a few minutes. If you enroll by telephone and we have any questions, we will follow up with you. A PhilRx representative will confirm your information (address and insurance information), explain the program and provide you with your insurance co-pay and delivery options. Please click here to read our Privacy Policy.

Coverage for Osphena^® is determined by your insurer. However, if your insurer places restrictions on coverage for Osphena^®, PhilRx will work with your doctor's office to help address any of these restrictions.

Patients who enroll in Osphena At Home^® may be eligible for the Osphena^® CoPay Savings Card. Remember that you must have a valid prescription for Osphena^® to be eligible for the savings offer. PhilRx will apply the Osphena^® CoPay Savings Card and let you know what your out-of-pocket cost will be.

No, shipping is included with your prescription order.

You may sign in to the patient portal to review your order status (instructions are included in initial shipment) or you may call the pharmacy at (844) 716-HOME (4663).

Yes, we offer a convenient refill service that will ensure that your prescription is refilled and shipped to you automatically every month for the length of your prescription. Using the automatic refill service means PhilRx will keep your credit card number on file. If you prefer that PhilRx not keep your credit card number on file, you may call the pharmacy and request a refill at any time.

Yes, we would be happy to call your doctor on your behalf. You and your doctor should talk regularly about whether or not you still need treatment with Osphena^®.

Yes, we can provide you with additional information regarding the product. When we ship your order, it will include some patient information about Osphena^® to help you get started.

Call us at (844) 716-HOME (4663) and we will assist you in transferring your prescription to PhilRx.

You need a valid prescription for Osphena^® to enroll in the Osphena At Home^® program. We suggest that you talk to your healthcare provider to see if Osphena^® is right for you.

Please visit the Osphena^® Savings page for details.

No, the Osphena^® CoPay Savings Card does not need to be activated before you use it.

The Osphena^® CoPay Savings Card does not require that patients wait a specific number of days between prescription refills; however, your individual insurer may limit how quickly they will approve your monthly refill. It is recommended that you check with your insurance provider for details.

Yes. The Osphena^® CoPay Savings Card may be used with mail-order purchases with a valid prescription. To redeem the offer, simply provide your mail-order pharmacy with the Osphena^® CoPay Savings Card information.

If you misplace or damage your Osphena^® CoPay Savings Card, you can download a new one. Your pharmacy may also keep a record of your Osphena^® CoPay Savings Card on file.

Although some pharmacies may keep your Osphena^® CoPay Savings Card information on file, it’s best to always bring your Osphena^® CoPay Savings Card to the pharmacy with your valid Osphena^® prescription or refill request.

No, you can only use one Osphena^® CoPay Savings Card at a time. Your Osphena^® CoPay Savings Card is valid for several uses. You do not need to use a different card each time. Your pharmacy may also keep a record of your Osphena^® CoPay Savings Card on file so that you do not have to show your card each time.

Yes. Your out-of-pocket expense can be applied to your deductible.

Yes. The Osphena^® CoPay Savings Card is for use ONLY with a valid Osphena^® prescription.

The Osphena^® CoPay Savings Card is accepted at most retail pharmacies in the United States and Puerto Rico. If a pharmacy decides not to accept the offer, you may receive savings by requesting a rebate check after you have purchased your Osphena^® prescription. Simply call the number on the back of your Osphena^® CoPay Savings Card for information on how to submit a request for reimbursement.

Duchesnay USA does not offer a patient assistance program at this time.

Yes. Even if you have previously used an Osphena^® CoPay Savings Card, you may present a valid prescription at the pharmacy with your new savings card and you will be eligible for the new offer.